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©2023 CAMCEVI. All rights reserved. WS-CAM-2200006 V2

Getting started

Choosing your treatment

Your healthcare professional has several options for managing advanced prostate cancer. There are many reasons why CAMCEVI® might be right for you.

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Leuprolides have shown to be effective in treating advanced prostate cancer1

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Consistent testosterone level reduction from week 4 out to 6 months1

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Reduction in testosterone levels by week 4 after the initial dose1

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Consistent testosterone level reduction from week 4 out to 6 months1

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Subcutaneous injection means the injection is given in the fatty tissue, just under the skin1

Injection Sites

Injection Sites image
Injection Sites image

Receiving Your injection

You can only receive CAMCEVI injections from your healthcare provider. The proper dose is injected into the fatty tissue just under your skin in your abdomen.1 As long as CAMCEVI is working for you, your healthcare provider will repeat the injection every 6 months.

Talking with Your Healthcare professional

It can be helpful to take a list of questions to your appointment so you remember everything you wanted to discuss. The following are some general suggestions to help you make the most of your appointments.

Doctor patient image
Doctor patient image

Questions
about CAMCEVI

  • How often will I get a CAMCEVI injection?
  • What are the side effects? Are there ways to help manage them?
  • Who should not take CAMCEVI?
  • Are there any medications or things I should avoid while taking CAMCEVI?
  • How will we know if CAMCEVI is working for me?
  • Are there situations when I should contact my healthcare professional?

Questions about treating advanced prostate cancer

  • What role does testosterone play in my advanced prostate cancer?
  • What are the treatment choices for my stage of advanced prostate cancer?
  • Are there additional tests I will need throughout my treatment (testosterone levels, blood pressure, blood sugar levels, lipids)?
  • What is the difference between hormone-blocking therapies?

Questions about living with advanced prostate cancer

  • Is there any type of diet I should follow, or foods I should avoid?
  • What are the effects of smoking and/or alcohol on my cancer?
  • What type of exercise is best for me?
  • Are there certain activities I should avoid?
  • How can I manage my stress levels?
  • What about other medications, prescription or otherwise? Is there anything I shouldn’t be taking?

Help for managing side effects

If you experience side effects while taking CAMCEVI, it’s important to discuss them with your healthcare provider, as they may have advice on how to manage them. The following tips may also help, but it’s important to remember that this information doesn’t replace the advice of your provider. Be sure to notify them if symptoms or side effects worsen.

hot-flash

Hot Flash

CAMCEVI can cause hot flashes. You may experience them as a rush of warmth in your upper torso, followed by excessive perspiration. It may help to dress in layers and open windows or use a fan while you sleep. It’s also a good idea to keep a diary of triggers so you can avoid them. Your healthcare professional may have more advice.2

high-blood-pressure

High Blood Pressure

It’s important for all adults to try to maintain a healthy blood pressure, which you can monitor at home. Ask your healthcare provider if certain blood pressure numbers should trigger a phone call to their office. Be sure to take any blood pressure medication as directed by your provider. Some ways to manage blood pressure and overall heart health include eating a healthy, low-salt diet, quitting smoking, and getting regular physical activity.3 Your care team may have other ideas about lowering your blood pressure risks.4

injection-site-reaction

Injection site reactions

CAMCEVI is given as an injection, which may cause temporary burning or stinging, pain, bruising, or redness at the injection site.1 Your healthcare professional may offer advice about over-the-counter pain medication and/or using ice packs to help relieve your symptoms.5 Do not apply heat directly to the area where the shot was given.

pain

Pain in extremity, such as the neck, shoulders, arms, and legs

Be sure to report any pain to your care team. They may suggest you try over-the-counter medications6 or non-medical therapies like yoga, gentle stretching, and exercise7 that may help to reduce pain. Sticking to a schedule and taking medicine exactly as prescribed may help with pain control.8

tiredness

Tiredness/fatigue

If you find that you are more tired after receiving CAMCEVI, there may be some steps you can take to help. For example, lifestyle changes—such as staying or becoming more physically active and getting proper nutrition—may help you cope with fatigue. Make sure to tell your care team how you are feeling so they can tailor their advice for you.9

increase-bs-level

INCREASED BLOOD SUGAR

You may be at risk for increased blood sugar when you take CAMCEVI. Talk to your healthcare professional about monitoring your blood sugar levels.1

heart-health

HEART HEALTH

Your heart health may be affected while taking CAMCEVI. Be sure to speak to your healthcare professional about the best way to monitor for any symptoms or signs of concern.1

IMPORTANT SAFETY INFORMATION

What is CAMCEVI®? CAMCEVI is an androgen deprivation therapy (ADT) used for treatment of adult patients with advanced prostate cancer.

You should not take CAMCEVI if you have ever had an allergic reaction to any of the ingredients in CAMCEVI or to any other medications called gonadotropin-releasing hormone (GnRH) agonists.

CAMCEVI may:

Cause an increase in your testosterone level during the initial few weeks of treatment, which may cause temporary worsening of symptoms or additional signs and symptoms of prostate cancer. You may experience a temporary increase in bone pain. You may have trouble with urination or develop abnormal amount of pressure on your spinal cord which can result in paralysis, which may be life-threatening.

Cause your blood sugar to increase, including increasing your risk of developing diabetes. You should have your blood sugar monitored while taking CAMCEVI.

Increase your risk of heart problems including heart attack, sudden death, or stroke. It can also cause your heart to beat irregularly.

Cause some patients to have seizures.

Cause fetal harm if administered to a pregnant woman.

Cause impotence and impair fertility in males of reproductive potential.

The most common side effects of CAMCEVI include hot flush, high blood pressure, reaction where you received your shot which may cause temporary burning/stinging, pain, bruising or redness, upper respiratory tract infections, muscle and bone pain, tiredness, and pain in extremities. Tell your healthcare provider if you experience a rash or severe injection site reaction.

For more information, talk to your healthcare provider.

These are not all the possible side effects of CAMCEVI. For additional information, see the full prescribing information or ask your healthcare professional or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA at 1-800-FDA-1088 or visit
www.fda.gov/medwatch.

Click here for full Prescribing Information.

References:

1. CAMCEVI. Prescribing information. Accord BioPharma; May 2021. 2. UroToday. APCCC 2019: Management of Hot Flushes. Published August 2019. Accessed January 27, 2022. https://www.urotoday.com/conference-highlights/apccc-2019/114664-apccc-2019-management-of-hot-flushes.html 3. Centers for Disease Control and Prevention. Getting Blood Pressure Under Control. Published September 2012. Accessed January 27, 2022. https://www.cdc.gov/vitalsigns/hypertension/index.html 4. American Cancer Society. Protect Your Heart During Cancer Treatment. Published February 2020. Accessed January 27, 2022. https://www.cancer.org/latest-news/protect-your-heart-during-cancer-treatment.html 5. Saint Luke’s Hospital of Kansas City. Understanding Post-Injection Inflammation. Accessed January 27, 2022. https://www.saintlukeskc.org/health-library/understanding-post-injection-inflammation 6. BC Cancer Agency Cancer Drug Manual. For the Patient: Leuprolide injection, version 9.1994. Accessed February 15, 2022. http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Leuprolide_handout_1July08.pdf 7. OncoLink. Updated July 8, 2019. Accessed February 15, 2022. https://www.oncolink.org/cancer-treatment/oncolink-rx/leuprolide-acetate-lupron-r-lupron-depot-r-eligard-r-prostap-r-viadur-r-for-men 8. American Cancer Society. Managing Cancer Pain at Home. Accessed January 27, 2022. https://www.cancer.org/treatment/treatments-and-side-effects/physical-side-effects/pain/pain.html 9. ASCO. Fatigue. Published April 2020. Accessed February 2, 2022. https://www.cancer.net/coping-with-cancer/physical-emotional-and-social-effects-cancer/managing-physical-side-effects/fatigue